This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation,ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.

Dr. PV. Mohanan is a Fellow of the National Academy of Science and Royal Society of Biologists, UK. He was a JSPS Post-Doctoral Fellow at the University of Tsukuba, Japan, in the field of Neurotoxicity. He joined Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Govt. of India, in 1989. As a toxicologist, he has been intimately associated with all the medical devices/technologies developed at SCTIMST. Currently, he heads the Division of Toxicology and a visiting professor and visiting researcher at Toyo University, Japan, and a Certified Biological Safety Specialist. He received a lifetime achievement award from the Society of Toxicology India for the outstanding contribution to toxicology research. Dr. Mohanan made significant contributions to the development of medical device regulations in India. He received a certificate of appreciation from the Hon. Minister of Science and Technology, Govt. of India, contributed to getting full adherent status on GLP from the OECD. He has authored more than 250 publications and edited 4 books. Presently, he is the Secretary-General of Society of Toxicology, India, and General Secretary of Indian JSPS Alumni Association.

Chapter 1. A Historical and Technological Background to Organs-on-a-Chip.- Chapter 2. Applications of microfluidics.- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies.- Chapter 4. Microfluidics in Chemical biology.- Chapter 5. Role of microfluidics in drug delivery.- Chapter 6. Microfluidics in drug discovery.- Chapter 7. Microfludic based sensors.- Chapter 8. Background and Organs-on-a-Chip.- Chapter 9. Culture and co-culture of cells for multi organ on chip.- Chapter 10.Cells and organs on a chip in biomedical sciences.- Chapter 11. Futuristic aspects of organ on a chip.- Chapter 12. Development of Human on a chip.- Chapter 13. Multi-organ on a chip for personalized medicine.- Chapter 14. Development and application of Microfluids in organoid formation.- Chapter 15. Liver on a chip.- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface.- Chapter 17. Microfluidic retina-on-chip.- Chapter 18. Heart on a chip.- Chapter 19. Kidney on a chip.- Chapter 20. Lungs on a chip.- Chapter 21. Brain on a chip.- Chapter 22. Skin on a chip.- Chapter 23. Organs-on-a-chip in preclinical studies.- Chapter 24. Application of organ on chip in blood brain barrier model.- Chapter 25. Multi organs on a chip in disease modeling.- Chapter 26. Prospects of Medical device on a chip.- Chapter 27. Lab on a chip for precision Medicine.- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation.- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.