The future is now--this groundbreaking textbook illustrates how biotechnology has radically changed the way we think about health careBiotechnology is delivering not only new products to diagnose, prevent, and treat human disease but entirely new approaches to a wide range of difficult biomedical challenges. Because of advances in biotechnology, hundreds of new therapeutic agents, diagnostic tests, and vaccines have been developed and are available in the marketplace.In this jargon-free, easy-to-read textbook, the authors demystify the discipline of medical biotechnology and present a roadmap that provides a fundamental understanding of the wide-ranging approaches pursued by scientists to diagnose, prevent, and treat medical conditions.Medical Biotechnology is written to educate premed and medical students, dental students, pharmacists, optometrists, nurses, nutritionists, genetic counselors, hospital administrators, and individuals who are stakeholders in the understanding and advancement of biotechnology and its impact on the practice of modern medicine.Hardcover, 700 pages, full-color illustrations throughout, glossary, index.

PrefaceAbout the AuthorsSection I: The Biology behind the TechnologyChapter 1: Fundamental TechnologiesMolecular CloningGenomic LibrariesAmplification of DNA Using PCRDNA Sequencing TechnologiesSequencing Whole GenomesGenomicsChapter 2: Fundamental Concepts in ImmunologyThe Immune ResponseFunctions of the Immune SystemCells of the Immune System: Cell-MediatedTissues of the Immune SystemHumoral ImmunityTypes of Antibodies: ApplicationsImmunological TechniquesChapter 3: The Genetic Basis of DiseaseChromosomal Disorders and Gene MappingSingle-Gene DisordersPolygenic Disorders and Gene ClusteringMitochondrial DisordersChapter 4: Immune PathogenesisModels of Immune System LesionsInflammation and Immune HypersensitivityImmunodeficiency Disorders and Defects in Development of the Immune SystemChapter 5: Microbial PathogenesisIntroductionBacterial InfectionsViral InfectionsSection II: Production of Therapeutic AgentsChapter 6: Modulation of Gene ExpressionManipulating Gene Expression in ProkaryotesHeterologous Protein Production in Eukaryotic CellsDirected MutagenesisChapter 7: Genetic Engineering of PlantsPlant Transformation with the Ti Plasmid of A. tumefaciensPhysical Transfer of Genes to PlantsChloroplast EngineeringTransient Gene ExpressionMolecular PharmingEdible VaccinesSection III: Diagnosing and Treating Human DiseaseChapter 8: Molecular DiagnosticsImmunological Approaches to Detect Protein Biomarkers of DiseaseDNA-Based Approaches to Disease DiagnosisDetecting RNA Signatures of DiseaseChapter 9: Protein TherapeuticsPharmaceuticalsRecombinant AntibodiesEnzymesLactic Acid BacteriaChapter 10: Nucleic Acid Therapeutic Agents and Human Gene TherapyTreating Genetic and Nongenetic DisordersTargeting Specific mRNAs and DNAsViral Delivery SystemsNonviral Nucleic Acid Delivery SystemsGene TherapyChapter 11: VaccinesVaccination: OverviewSubunit VaccinesPeptide VaccinesDendritic Cell VaccinesDNA VaccinesAttenuated VaccinesVector VaccinesAdjuvantsSystems Biology and Evaluation of VaccinesChapter 12: Societal IssuesSafety and Ethical IssuesPatenting BiotechnologyEconomic IssuesGlossaryIndex